Article
Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation.
Advances in space research : the official journal of the Committee on Space Research (COSPAR) - 1 Jan 2001
Hei T K, Zhao Y L, Roy D, Piao C Q, Calaf G, Hall E J
Abstract excerpt
Carcinogenesis is a multi-stage process with sequence of genetic events governing the phenotypic expression of a series of transformation steps leading to the development of metastatic cancer. In the present study, immortalized human bronchial (BEP2D) and breast (MCF-10F) cells were irradiated with graded doses of either 150 keV/micrometer alpha particles or 1 GeV/nucleon 56Fe ions. Transformed cells developed...
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