Article
Progress and prospects: gene therapy for mitochondrial DNA disease.
Gene therapy - 1 Jul 2008
Kyriakouli D S, Boesch P, Taylor R W, Lightowlers R N
Abstract excerpt
Defects of the mitochondrial genome cause a wide variety of clinical disorders. Except for rare cases where surgery or transplant is indicated, there is no effective treatment for patients. Genetic-based therapies are consequently being considered. On account of the difficulties associated with mitochondrial (mt) transfection, alternative approaches whereby mitochondrial genes can be engineered and introduced...
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