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Article

Role of metal ions in the hydrolysis reaction catalyzed by RNase P RNA from Bacillus subtilis.

Journal of molecular biology - 9 Jul 1999

Warnecke J M, Held R, Busch S, Hartmann R K

Abstract excerpt

Precursor tRNA (ptRNA) substrates carrying a single Rp or Sp-phosphorothioate modification at the RNase P cleavage site were used as tools to study the cleavage mechanism of RNase P RNA from Bacillus subtilis. Both the Sp and the Rp-diastereomer reduced the rate of processing at least 10(4)-fold under conditions where the chemical step is essentially rate-limiting. Neither the Rp nor the Sp-phosphorothioate...

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Source

Identifiers

PMID: 10390342
DOI: 10.1006/jmbi.1999.2890

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Role of metal ions in the hydrolysis reaction catalyzed by RNase P RNA from Bacillus subtilis.PMID 10390342Read ↗

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