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Article

Disease-causing mutations in cardiac troponin T: identification of a critical tropomyosin-binding region.

Biophysical journal - 1 Nov 2001

Palm T, Graboski S, Hitchcock-DeGregori S E, Greenfield N J

Abstract excerpt

Fifteen percent of the mutations causing familial hypertrophic cardiomyopathy are in the troponin T gene. Most mutations are clustered between residues 79 and 179, a region known to bind to tropomyosin at the C-terminus near the complex between the N- and C-termini. Nine mutations were introduced into a troponin T fragment, Gly-hcTnT(70-170), that is soluble, alpha-helical, binds to tropomyosin, promotes the...

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Identifiers

PMID: 11606294
DOI: 10.1016/S0006-3495(01)75924-3
PMCID: PMC1301748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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