Article
Patients with familial hypertrophic cardiomyopathy caused by a Phe110Ile missense mutation in the cardiac troponin T gene have variable cardiac morphologies and a favorable prognosis.
Circulation - 4 Aug 1998
Anan R, Shono H, Kisanuki A, Arima S, Nakao S, Tanaka H
Abstract excerpt
BACKGROUND: Mutations that cause familial hypertrophic cardiomyopathy have been identified in several genes that encode contractile proteins. Patients with mutations in the cardiac troponin T (cTnT) gene have particularly poor prognosis but only mild hypertrophy. To date, no benign mutation in th...
Topics
- Adult
- Aged
- Alleles
- Base Sequence
- Cardiomyopathy, Hypertrophic
- Female
- Genetic Markers
- Genotype
- Haplotypes
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Myocardium
- Pedigree
- Phenotype
- Prognosis