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Article

Effects of two familial hypertrophic cardiomyopathy-causing mutations on alpha-tropomyosin structure and function.

Biochemistry - 15 Apr 1997

Golitsina N, An Y, Greenfield N J, Thierfelder L, Iizuka K, Seidman J G, Seidman C E, Lehrer S S, Hitchcock-DeGregori S E

Abstract excerpt

Missense mutations in alpha-tropomyosin can cause familial hypertrophic cardiomyopathy. The effects of two of these, Asp175Asn and Glu180Gly, have been tested on the structure and function of recombinant human tropomyosin expressed in Escherichia coli. The F-actin affinity (measured by cosedimentation) of Glu180Gly was similar to that of wild-type, but Asp175Asn was more than 2-fold weaker, whether or not...

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Identifiers

PMID: 9109674
DOI: 10.1021/bi962970y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of two familial hypertrophic cardiomyopathy-causing mutations on alpha-tropomyosin structure and function.PMID 9109674Read ↗

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