Article
Alternative RNA editing produces a novel protein involved in mitochondrial DNA maintenance in trypanosomes.
Molecular and cellular biology - 1 Sept 2008
Ochsenreiter Torsten, Anderson Sedrick, Wood Zachary A, Hajduk Stephen L
Abstract excerpt
The mitochondrial genome of trypanosomes is composed of thousands of topologically interlocked circular DNA molecules that form the kinetoplast DNA (kDNA). Most genes encoded by the kDNA require a posttranscriptional modification process called RNA editing to form functional mRNAs. Here, we show that alternative editing of the mitochondrial cytochrome c oxidase III (COXIII) mRNA in Trypanosoma brucei produces a...
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