Article

mtTF1: A Novel Factor Involved in Mitochondrial Gene Expression in <i>Trypanosoma brucei</i>

2025-05-23

Abstract excerpt

<h4>Summary</h4> Mitochondrial DNA replication and gene expression are essential for cell survival. In Trypanosoma brucei , a protozoan animal and human parasite, the mitochondrial RNA polymerase (mtRNAP) plays roles in both transcription and DNA replication. This study identifies and characterizes the first mitochondrial transcription factor (mtTF1) in the Kinetoplastea. mtRNAP and mtTF1 form a high-molecular-w...

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Literature Corpus work: f2985407-c78e-5e3e-a3bf-b186e77ddca5
DOI: 10.1101/2025.05.22.655275

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