Article
Genetic and functional analysis of the human immunodeficiency virus (HIV) type 1-inhibiting F12-HIVnef allele.
The Journal of general virology - 1 Nov 2001
D'Aloja Paola, Santarcangelo Anna Claudia, Arold Stefan, Baur Andreas, Federico Maurizio
Abstract excerpt
The primary human immunodeficiency virus type 1 (HIV-1) Nef mutant F12-HIVNef is characterized by three rare amino acid substitutions, G(140)E, V(153)L and E(177)G. It was reported previously that the expression of F12-HIVNef in the context of the highly productive NL4-3 HIV-1 strain blocks virus replication at the level of virus assembly and/or release by a mechanism depending on the presence of the CD4...
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