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Article

Functional separation of endosomal fusion factors and the class C core vacuole/endosome tethering (CORVET) complex in endosome biogenesis.

The Journal of biological chemistry - 15 Feb 2013

Cabrera Margarita, Arlt Henning, Epp Nadine, Lachmann Jens, Griffith Janice, Perz Angela, Reggiori Fulvio, Ungermann Christian

Abstract excerpt

Transport along the endolysosomal system requires multiple fusion events at early and late endosomes. Deletion of several endosomal fusion factors, including the Vac1 tether and the Class C core vacuole/endosome tethering (CORVET) complex-specific subunits Vps3 and Vps8, results in a class D vps phenotype. As these mutants have an apparently similar defect in endosomal transport, we asked whether CORVET and Vac1...

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Source

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Identifiers

PMID: 23264632
DOI: 10.1074/jbc.M112.431536
PMCID: PMC3576121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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