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Article

Rab5-mediated endosome formation is regulated at the trans-Golgi network.

Communications biology - 1 Jan 2019

Nagano Makoto, Toshima Junko Y, Siekhaus Daria Elisabeth, Toshima Jiro

Abstract excerpt

Early endosomes, also called sorting endosomes, are known to mature into late endosomes via the Rab5-mediated endolysosomal trafficking pathway. Thus, early endosome existence is thought to be maintained by the continual fusion of transport vesicles from the plasma membrane and the trans-Golgi network (TGN). Here we show instead that endocytosis is dispensable and post-Golgi vesicle transport is crucial for the...

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Identifiers

PMID: 31754649
DOI: 10.1038/s42003-019-0670-5
PMCID: PMC6858330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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