Adverse effect of the CCR5 promoter -2459A allele on HIV-1 disease progression.

Abstract excerpt

HIV positive individuals heterozygous for a 32 basepair deletion in the CCR5 encoding gene (CCR5 Delta32) have a reduced number of CCR5 receptors on the cell surface and a slower progression towards AIDS and death. Other human polymorphisms, such as the CCR2 64I and the CCR5 promoter -2459 A/G transition that has been discovered recently, have also been shown to influence HIV progression. Since genetic linkages...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cohort Studies
• Share to Disease Progression
• Share to HIV-1