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Article

Functional reassessment of P16 variants using a transfection-based assay.

International journal of cancer - 19 Jul 1999

Walker G J, Gabrielli B G, Castellano M, Hayward N K

Abstract excerpt

CDKN2A appears to be the major melanoma susceptibility gene, and is also mutated/deleted in sporadic tumours of various types including melanoma. Thus far most approaches to assessing the functionality of mutations in this gene have used in vitro methods such as CDK4 binding and kinase inhibition assays, with sometimes disparate conclusions about functional significance of some variants between studies. We have...

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Share to Cyclin-Dependent Kinase Inhibitor p16
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Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique, Indirect

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Source

Identifiers

PMID: 10389768
DOI: 10.1002/(sici)1097-0215(19990719)82:2<305::aid-ijc24>3.0.co;2-z

Genes

CDK4
CDK6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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