Exploring the Role of p53 in Radiosensitivity: A Key Player in Cancer Therapy

Abstract excerpt

Radiotherapy remains a cornerstone in cancer treatment, leveraging ionizing radiation to eradicate malignant cells. Its efficacy, however, is frequently challenged by the heterogeneous sensitivity of tumors and surrounding tissues to radiation. Therefore, understanding the molecular mechanisms underlying radiosensitivity is crucial for improving treatment outcomes. Among the myriad of molecular players involved, t...

Topics

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• Apoptosis
• Cancer-related Molecular Pathways
• Cell death mechanisms and regulation
• DNA Damage
• DNA Repair Mechanisms
• Mutation
• Neoplasms
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

b07de2f4-9cd3-5ec6-8958-3bd565172e05

DOI

10.20944/preprints202408.2103.v1