Article
Absence of Dbp2p alters both nonsense-mediated mRNA decay and rRNA processing.
Molecular and cellular biology - 1 Nov 2001
Bond A T, Mangus D A, He F, Jacobson A
Abstract excerpt
Dbp2p, a member of the large family of DEAD-box proteins and a yeast homolog of human p68, was shown to interact with Upf1p, an essential component of the nonsense-mediated mRNA decay pathway. Dbp2p:Upf1p interaction occurs within a large conserved region in the middle of Upf1p that is largely distinct from its Nmd2p and Sup35/45p interaction domains. Deletion of DBP2, or point mutations within its highly...
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