Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling.

eLife - 13 Mar 2020

Shen Hua, Gan Peiheng, Wang Kristy, Darehzereshki Ali, Wang Kai, Kumar S Ram, Lien Ching-Ling, Patterson Michaela, Tao Ge, Sucov Henry M

Abstract excerpt

Injury to the newborn mouse heart is efficiently regenerated, but this capacity is lost by one week after birth. We found that IGF2, an important mitogen in heart development, is required for neonatal heart regeneration. IGF2 originates from the endocardium/endothelium and is transduced in cardiomyocytes by the insulin receptor. Following injury on postnatal day 1, absence of IGF2 abolished injury-induced cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Diploidy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation

Share to Insulin-Like Growth Factor II

Share to Mice, Knockout

Share to Myocytes, Cardiac

Share to Regeneration

Source

Open in PubMed Open full text

Identifiers

PMID: 32167474
DOI: 10.7554/eLife.53071
PMCID: PMC7105374

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mononuclear diploid cardiomyocytes support neonatal mouse heart regeneration in response to paracrine IGF2 signaling.PMID 32167474Read ↗

The Insulin-like Growth Factor Signalling Pathway in Cardiac Development and RegenerationSemantic proximity Read ↗

A neonatal blueprint for cardiac regenerationSemantic proximity Read ↗

Reawakening the Intrinsic Cardiac Regenerative Potential: Molecular Strategies to Boost Dedifferentiation and Proliferation of Endogenous CardiomyocytesSemantic proximity Read ↗

Igf Signaling is Required for Cardiomyocyte Proliferation during Zebrafish Heart Development and RegenerationSemantic proximity Read ↗

Cardiac regeneration based on mechanisms of cardiomyocyte proliferation and differentiationSemantic proximity Read ↗

Building and re-building the heart by cardiomyocyte proliferationSemantic proximity Read ↗

Cardiomyocyte proliferation and progenitor cell recruitment underlie therapeutic regeneration after myocardial infarction in the adult mouse heartSemantic proximity Read ↗

Cardiomyocyte proliferation in zebrafish and mammals: lessons for human diseaseSemantic proximity Read ↗

Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretationsSemantic proximity Read ↗

Two decades of heart regeneration research: Cardiomyocyte proliferation and beyondSemantic proximity Read ↗

Cardiomyocyte-fibroblast crosstalk in the postnatal heartSemantic proximity Read ↗

FGF-2 controls the differentiation of resident cardiac precursors into functional cardiomyocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.