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An Extensive Genetic Program Occurring during Postnatal Growth in Multiple Tissues

26 Nov 2008

Abstract excerpt

Mammalian somatic growth is rapid in early postnatal life but then slows and eventually ceases in multiple tissues. We hypothesized that there exists a postnatal gene expression program that is common to multiple tissues and is responsible for this coordinate growth deceleration. Consistent with this hypothesis, microarray analysis identified more than 1600 genes that were regulated with age (1 vs. 4 wk)...

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PMID: 19036884
DOI: 10.1210/en.2008-0868

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