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Article

Notch1 functions as a negative regulator of lymphatic endothelial cell differentiation in the venous endothelium.

Development (Cambridge, England) - 1 Jun 2013

Murtomaki Aino, Uh Minji K, Choi Yun K, Kitajewski Christopher, Borisenko Valeriya, Kitajewski Jan, Shawber Carrie J

Abstract excerpt

In development, lymphatic endothelial cells originate within veins and differentiate via a process requiring Prox1. Notch signaling regulates cell-fate decisions, and expression studies suggested that Jag1/Notch1 signaling functions in veins during lymphatic endothelial specification. Using an inducible lymphatic endothelial Prox1CreER(T2) driver, Notch signaling was suppressed by deleting Notch1 or expressing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 23615281
DOI: 10.1242/dev.083865
PMCID: PMC3653558

Genes

LYVE1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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