Article
Polygenic control of autoimmune peripheral nerve inflammation in rat.
Journal of neuroimmunology - 1 Oct 2001
Dahlman I, Wallström E, Jiao H, Luthman H, Olsson T, Weissert R
Abstract excerpt
Experimental autoimmune neuritis (EAN) is the principal animal model for Guillain-Barré syndrome (GBS), an inflammatory disease of the peripheral nervous system. Little is known on the genetic regulation of these diseases. We provide the first genetic linkage analysis of EAN. Susceptibility to EAN in a rat F2 population segregated with high levels of anti-PNM IgG, as well as IgG2b and IgG2c isotype levels, which...
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