Inflammation and susceptibility to neurodegeneration: the use of unbiased genetics to decipher critical regulatory pathways.

Abstract excerpt

Neurodegeneration and signs of immune activation, with T cell infiltration, major histocompatibility complex class II expression and glial activation, occur in many neurological diseases. Although particular qualities of the inflammatory response have been proposed to be of importance, still very little is known about the exact factors that determine susceptibility to neurodegeneration. Mechanistic studies have...

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