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Article

Susceptibility of Nonpromoter CpG Islands to De Novo Methylation in Normal and Neoplastic Cells

3 Oct 2001

Abstract excerpt

BACKGROUND: Many cancers display alterations in methylation patterns of CpG islands--stretches of DNA rich in CpG dinucleotides often associated with gene promoters that are involved in initiation of gene transcription. This methylation may perturb expression of genes critical to the regulation of cell proliferation. Aberrant methylation is not limited to a few genes or to promoter regions but has been found on a...

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PMID: 11584062
DOI: 10.1093/jnci/93.19.1465

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