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Article

A new scale for side-chain contribution to protein stability based on the empirical stability analysis of mutant proteins.

Protein engineering - 1 Aug 2001

Takano K, Yutani K

Abstract excerpt

The hydrophobicity scales for amino acid side chains based on the transfer Gibbs energy (DeltaG(trans)) of amino acids from non-aqueous phases to water have been widely used to estimate the contribution of buried side chains to the conformational stability of proteins. In this paper, we propose a new scale for the side-chain contribution to protein stability, which is derived from data on protein denaturation...

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Identifiers

PMID: 11579219
DOI: 10.1093/protein/14.8.525

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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