Article
Computational evaluation of protein stability change upon mutations.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2010
Yin Shuangye, Ding Feng, Dokholyan Nikolay V
Abstract excerpt
When designing a mutagenesis experiment, it is often crucial to estimate the stability change of proteins induced by mutations (Delta DG). Despite the recent advances in computational methods, it is still challenging to estimate D DG quickly and accurately. We recently developed the Eris protocols for in silico evaluation of the Delta DG. Starting from the tertiary structure of the wide-type protein, the Eris...
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