Article
Mutations in the human homologue of the Drosophila segment polarity gene patched in oral squamous cell carcinoma cell lines.
In vitro cellular & developmental biology. Animal - 1 Jan 2000
Michimukai E, Kitamura N, Zhang Y, Wang H, Hiraishi Y, Sumi K, Hayashido Y, Toratani S, Okamoto T
Abstract excerpt
In the present study, we have analyzed tumor deoxyribonucleic acid from oral squamous cell carcinoma (OSCC) cells for patched mutations using an exon-by-exon single strand conformation polymorphism assay and direct sequencing. We found two missense mutations which affected the conserved residue in the transmembrane domains of the gene product and in the intracellular loop at the C-terminal residue implicated in...
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