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Article

PATCHED and p53 gene alterations in sporadic and hereditary basal cell cancer.

Oncogene - 22 Nov 2001

Ling G, Ahmadian A, Persson A, Undén A B, Afink G, Williams C, Uhlén M, Toftgård R, Lundeberg J, Pontén F

Abstract excerpt

It is widely accepted that disruption of the hedgehog-patched pathway is a key event in development of basal cell cancer. In addition to patched gene alterations, p53 gene mutations are also frequent in basal cell cancer. We determined loss of heterozygosity in the patched and p53 loci as well as sequencing the p53 gene in tumors both from sporadic and hereditary cases. A total of 70 microdissected samples from...

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Share to Basal Cell Nevus Syndrome
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11753655
DOI: 10.1038/sj.onc.1204946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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