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Article

Mutations in the human homologue of the Drosophila patched gene in esophageal squamous cell carcinoma.

Genes, chromosomes & cancer - 1 Mar 1998

Maesawa C, Tamura G, Iwaya T, Ogasawara S, Ishida K, Sato N, Nishizuka S, Suzuki Y, Ikeda K, Aoki K, Saito K, Satodate R

Abstract excerpt

The human homologue (PTCH) of the Drosophila segment polarity gene patched has recently been identified as a tumor-suppressor gene for nevoid basal cell carcinoma syndrome and for sporadic basal cell carcinomas of the skin. We analyzed 30 esophageal squamous cell carcinomas (ESCC) for intrageneic mutations of the PTCH gene by polymerase chain reaction-single-strand conformation polymorphism analysis followed by...

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PMID: 9523206

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations in the human homologue of the Drosophila patched gene in esophageal squamous cell carcinoma.PMID 9523206Read ↗

Mutations in the human homologue of Drosophila patched (PTCH) in basal cell carcinomas and the Gorlin syndrome: different in vivo mechanisms of PTCH inactivation.Semantic proximity Read ↗

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The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.Semantic proximity Read ↗

Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.Semantic proximity Read ↗

Most germ-line mutations in the nevoid basal cell carcinoma syndrome lead to a premature termination of the PATCHED protein, and no genotype-phenotype correlations are evident.Semantic proximity Read ↗

Isolation and characterization of human patched 2 (PTCH2), a putative tumour suppressor gene inbasal cell carcinoma and medulloblastoma on chromosome 1p32.Semantic proximity Read ↗

Somatic mutations in the human homologue of Drosophila patched in primitive neuroectodermal tumours.Semantic proximity Read ↗

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