Article
The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.
Nature genetics - 1 Sept 1996
Gailani M R, Ståhle-Bäckdahl M, Leffell D J, Glynn M, Zaphiropoulos P G, Pressman C, Undén A B, Dean M, Brash D E, Bale A E, Toftgård R
Abstract excerpt
Basal cell carcinoma (BCC) is the most common cancer in humans. The majority of sporadic BCCs have allele loss on chromosome 9q22 implying that inactivation of a tumour suppressor in this region is an important step in BCC formation. The gene for nevoid basal cell carcinoma syndrome (NBCCS), an a...
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