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Article

Striatal volume loss in HD as measured by MRI and the influence of CAG repeat

25 Sept 2001

Abstract excerpt

BACKGROUND: Huntington's disease (HD) is an autosomal dominant neurodegenerative disease that results from the expansion of a trinucleotide (CAG) repeat on chromosome 4. Progressive degeneration of the striatum is the pathologic hallmark of the disease. Little is known about the regional selectivity of the neurodegeneration and its relationship to the genetic expansion. METHODS: The authors used high-resolution...

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Identifiers

PMID: 11571328
DOI: 10.1212/wnl.57.6.1025

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