Article
Normal and mutant HTT interact to affect clinical severity and progression in Huntington disease.
Neurology - 20 Oct 2009
Aziz N A, Jurgens C K, Landwehrmeyer G B, van Roon-Mom W M C, van Ommen G J B, Stijnen T, Roos R A C
Abstract excerpt
OBJECTIVE: Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by a CAG repeat expansion in the HD gene (HTT). We aimed to assess whether interaction between CAG repeat sizes in the mutant and normal allele could affect disease severity and progression. METHODS: Using linear regression and mixed-effects models, the influence of mutant and normal CAG repeat sizes interaction was...
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