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Article

Neuronal NF1/RAS regulation of cyclic AMP requires atypical PKC activation

28 Jul 2014

Abstract excerpt

Neurofibromatosis type 1 (NF1) is a common neurodevelopmental disorder in which affected individuals are prone to learning, attention and behavioral problems. Previous studies in mice and flies have yielded conflicting results regarding the specific effector pathways responsible for NF1 protein (neurofibromin) regulation of neuronal function, with both cyclic AMP (cAMP)- and RAS-dependent mechanisms described....

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PMID: 25070947
DOI: 10.1093/hmg/ddu389

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