Article
Effect of a COL1A1 Sp1 binding site polymorphism on arterial pulse wave velocity: an index of compliance.
Hypertension (Dallas, Tex. : 1979) - 1 Sept 2001
Brull D J, Murray L J, Boreham C A, Ralston S H, Montgomery H E, Gallagher A M, McGuigan F E, Davey Smith G, Savage M, Humphries S E, Young I S
Abstract excerpt
-Reduced arterial compliance precedes changes in blood pressure, which may be mediated through alterations in vessel wall matrix composition. We investigated the effect of the collagen type I-alpha1 gene (COL1A1) +2046G>T polymorphism on arterial compliance in healthy individuals. We recruited 489 subjects (251 men and 238 women; mean age, 22.6+/-1.6 years). COL1A1 genotypes were determined using polymerase chain...
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