Article
Zebrafish smoothened functions in ventral neural tube specification and axon tract formation.
Development (Cambridge, England) - 1 Sept 2001
Varga Z M, Amores A, Lewis K E, Yan Y L, Postlethwait J H, Eisen J S, Westerfield M
Abstract excerpt
Sonic hedgehog (Shh) signaling patterns many vertebrate tissues. shh mutations dramatically affect mouse ventral forebrain and floor plate but produce minor defects in zebrafish. Zebrafish have two mammalian Shh orthologs, sonic hedgehog and tiggy-winkle hedgehog, and another gene, echidna hedgehog, that could have overlapping functions. To examine the role of Hedgehog signaling in zebrafish, we have...
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