Article
Notochord induction of zebrafish slow muscle mediated by Sonic hedgehog.
Genes & development - 1 Sept 1997
Blagden C S, Currie P D, Ingham P W, Hughes S M
Abstract excerpt
The patterning of vertebrate somitic muscle is regulated by signals from neighboring tissues. We examined the generation of slow and fast muscle in zebrafish embryos and show that Sonic hedgehog (Shh) secreted from the notochord can induce slow muscle from medial cells of the somite. Slow muscle...
Topics
- Animals
- Biological Evolution
- Embryonic Induction
- Hedgehog Proteins
- Immunohistochemistry
- Mesoderm
- Muscle Fibers, Fast-Twitch
- Muscle Fibers, Slow-Twitch
- Mutation
- Myosin Heavy Chains
- Notochord
- Proteins
- Time Factors
- Trans-Activators
- Zebrafish