Article
The zebrafish slow-muscle-omitted gene product is required for Hedgehog signal transduction and the development of slow muscle identity.
Development (Cambridge, England) - 1 May 2000
Barresi M J, Stickney H L, Devoto S H
Abstract excerpt
Hedgehog proteins mediate many of the inductive interactions that determine cell fate during embryonic development. Hedgehog signaling has been shown to regulate slow muscle fiber type development. We report here that mutations in the zebrafish slow-muscle-omitted (smu) gene disrupt many developmental processes involving Hedgehog signaling. smu(-/-) embryos have a 99% reduction in the number of slow muscle fibers...
Topics
- Animals
- Colforsin
- Cyclic AMP-Dependent Protein Kinases
- Gene Expression
- Genes
- Hedgehog Proteins
- Muscle Fibers, Slow-Twitch
- Muscle Proteins
- Muscle, Skeletal
- Mutagenesis
- Phenotype