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Article

Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation.

The EMBO journal - 3 Sept 2001

Damalas A, Kahan S, Shtutman M, Ben-Ze'ev A, Oren M

Abstract excerpt

Aberrant activation of beta-catenin contributes to the onset of a variety of tumors. We report that a tumor-derived beta-catenin mutant induces accumulation and activation of the p53 tumor suppressor protein. Induction is mediated through ARF, an alternative reading frame product of the INK4A tumor suppressor locus, in a manner partially dependent on the transcription factor E2F1. In wild-type mouse embryo...

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Share to ADP-Ribosylation Factors
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11532955
DOI: 10.1093/emboj/20.17.4912
PMCID: PMC125598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Deregulated beta-catenin induces a p53- and ARF-dependent growth arrest and cooperates with Ras in transformation.PMID 11532955Read ↗

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gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin.Semantic proximity Read ↗

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.Semantic proximity Read ↗

The oncogenic activation of beta-catenin.Semantic proximity Read ↗

Oncogenic Mutants of RON and MET Receptor Tyrosine Kinases Cause Activation of the β-Catenin PathwaySemantic proximity Read ↗

The alternative reading frame tumor suppressor inhibits growth through p21-dependent and p21-independent pathways.Semantic proximity Read ↗

ARF functions as a melanoma tumor suppressor by inducing p53-independent senescenceSemantic proximity Read ↗

P53 mutation as a source of aberrant beta-catenin accumulation in cancer cells.Semantic proximity Read ↗

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