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Article

Targeted degradation of beta-catenin by chimeric F-box fusion proteins.

Biochemical and biophysical research communications - 23 Jan 2004

Liu Jun, Stevens Jeffery, Matsunami Nori, White Raymond L

Abstract excerpt

Adenomatous polyposis coli (APC) tumor suppressor protein, together with Axin and glycogen synthase kinase 3beta (GSK-3beta), forms a Wnt-regulated signaling complex that mediates phosphorylation-dependent degradation of cytoplasmic beta-catenin by ubiquitin-dependent proteolysis. Degradation of...

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Source

Identifiers

PMID: 14706645
DOI: 10.1016/j.bbrc.2003.12.035

Genes

APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-14706645-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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