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Article

Pancreatic beta-cells expressing the Arg64 variant of the beta(3)-adrenergic receptor exhibit abnormal insulin secretory activity.

Journal of molecular endocrinology - 1 Oct 2001

Perfetti R, Hui H, Chamie K, Binder S, Seibert M, McLenithan J, Silver K, Walston J D

Abstract excerpt

The Arg64 beta(3)-adrenergic receptor (beta(3)AR) variant is associated with an earlier age of onset of diabetes and lower levels of insulin secretion in humans. The aims of this study were to investigate whether beta(3)AR is expressed by islet cells, if receptor binding affects insulin secretion and, finally, if the beta(3)AR Arg64 variant induces abnormal insulin secretory activity. Human pancreas extracts were...

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Source

Identifiers

PMID: 11564599
DOI: 10.1677/jme.0.0270133

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pancreatic beta-cells expressing the Arg64 variant of the beta(3)-adrenergic receptor exhibit abnormal insulin secretory activity.PMID 11564599Read ↗

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Beta 3-adrenergic receptor gene polymorphism and type 2 diabetes in a Caucasian population.Semantic proximity Read ↗

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