Article
Insulin response to glucose is lower in individuals homozygous for the Arg 64 variant of the beta-3-adrenergic receptor.
The Journal of clinical endocrinology and metabolism - 1 Nov 2000
Walston J, Silver K, Hilfiker H, Andersen R E, Seibert M, Beamer B, Roth J, Poehlman E, Shuldiner A R
Abstract excerpt
Type 2 diabetes mellitus (type 2 DM) is a polygenic disorder with a variable phenotype that includes both insulin resistance and insulin secretory dysfunction. The Arg 64 beta-3-adrenergic receptor variant allele is associated with an earlier age of onset of type 2 DM. The purpose of this study was to examine the in vivo pathophysiology of this variant allele to determine its contribution to the components of...
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