Beta 3-adrenergic receptor gene polymorphism and type 2 diabetes in a Caucasian population.

doi:10.1046/j.1463-1326.2001.00121.x

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Beta 3-adrenergic receptor gene polymorphism and type 2 diabetes in a Caucasian population.

Diabetes, obesity & metabolism - 1 Feb 2001

Oeveren van-Dybicz A M, Vonkeman H E, Bon M A, van den Bergh F A, Vermes I

Abstract excerpt

AIM: The beta 3-adrenergic receptor (beta 3-AR) is suspected to play a key role in the regulation of energy balance by increasing lipolysis and thermogenesis. A mutation in the beta 3-AR gene (Trp64Arg) has been associated with the capacity of weight gain and with early onset of noninsulin dependent diabetes mellitus (type 2 diabetes). In this study we investigated the prevalence of the two beta 3-AR alleles in a...

Topics

Adult
Aged
Alleles
Arginine
DNA
Deoxyribonucleases, Type II Site-Specific
Diabetes Mellitus, Type 2
Female
Gene Frequency
Heterozygote
Homozygote

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Leukocytes

Male

Middle Aged

Mutation

Polymerase Chain Reaction

Polymorphism, Restriction Fragment Length

Source

Open in PubMed

Identifiers

PMID: 11213599
DOI: 10.1046/j.1463-1326.2001.00121.x

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Beta 3-adrenergic receptor gene polymorphism and type 2 diabetes in a Caucasian population.PMID 11213599Read ↗

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