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Article

Trp64Arg variant of the beta3-adrenoceptor and insulin resistance in obese postmenopausal women.

The Journal of clinical endocrinology and metabolism - 1 Nov 1998

García-Rubi E, Starling R D, Tchernof A, Matthews D E, Walston J D, Shuldiner A R, Silver K, Poehlman E T, Calles-Escandón J

Abstract excerpt

There is controversy regarding the role of the Trp64Arg variant of the beta3-adrenergic receptor (beta3AR) gene in the pathogenesis of insulin resistance. The modest effect of the variant as well as differences in study design, gender, age, and genetic background may contribute to divergent results among investigations. Insulin sensitivity (euglycemic clamp and tracers) was measured in 13 obese women (57 +/- 6 yr...

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Identifiers

PMID: 9814483
DOI: 10.1210/jcem.83.11.5225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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Trp64Arg variant of the beta3-adrenoceptor and insulin resistance in obese postmenopausal women.PMID 9814483Read ↗

Obesity-related phenotypes and the beta3-adrenoceptor gene variant in postmenopausal women.Semantic proximity Read ↗

TRP64ARG beta 3-adrenergic receptor and obesity in Mexican Americans.Semantic proximity Read ↗

Energy expenditure, body composition and insulin response to glucose in male twins discordant for the Trp64Arg polymorphism of the beta3-adrenergic receptor gene.Semantic proximity Read ↗

Post-exercise oxidative stress and obesity in postmenopausal women: the role of beta3-adrenergic receptor polymorphism.Semantic proximity Read ↗

The Trp64Arg mutation of the beta3-adrenergic receptor is associated with hyperglycemia and current body mass index in Jamaican women.Semantic proximity Read ↗

Association of the beta3-adrenergic receptor Trp64Arg polymorphism with common metabolic traits: studies of 7605 middle-aged white people.Semantic proximity Read ↗

Identification of an interactive effect of beta3- and alpha2b-adrenoceptor gene polymorphisms on fat mass in Caucasian women.Semantic proximity Read ↗

The Trp64Arg mutation of the adrenergic beta-3 receptor gene impairs insulin secretion: a twin study.Semantic proximity Read ↗

Impaired capacity to lose visceral adipose tissue during weight reduction in obese postmenopausal women with the Trp64Arg beta3-adrenoceptor gene variant.Semantic proximity Read ↗

Relation of Trp64Arg polymorphism of beta 3-adrenergic receptor gene to adipocytokines and fat distribution in obese patients.Semantic proximity Read ↗

beta(3)-adrenergic receptor polymorphism and metabolic syndrome in postmenopausal women.Semantic proximity Read ↗

Trp64Arg mutation in beta 3-adrenoceptor gene of doubtful significance for obesity and insulin resistance.Semantic proximity Read ↗

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