Article
Trp64Arg variant of the beta3-adrenoceptor and insulin resistance in obese postmenopausal women.
The Journal of clinical endocrinology and metabolism - 1 Nov 1998
García-Rubi E, Starling R D, Tchernof A, Matthews D E, Walston J D, Shuldiner A R, Silver K, Poehlman E T, Calles-Escandón J
Abstract excerpt
There is controversy regarding the role of the Trp64Arg variant of the beta3-adrenergic receptor (beta3AR) gene in the pathogenesis of insulin resistance. The modest effect of the variant as well as differences in study design, gender, age, and genetic background may contribute to divergent resul...
Topics
- Aged
- Amino Acid Substitution
- Arginine
- Case-Control Studies
- Female
- Genetic Carrier Screening
- Genetic Variation
- Glucose Clamp Technique
- Humans
- Insulin Resistance
- Middle Aged
- Obesity
- Postmenopause
- Receptors, Adrenergic, beta
- Tryptophan