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Article

Do gene polymorphisms alone or in combination affect the function of human beta3-adrenoceptors?

British journal of pharmacology - 1 Jan 2009

Vrydag Wim, Alewijnse Astrid E, Michel Martin C

Abstract excerpt

BACKGROUND AND PURPOSE: beta(3)-Adrenoceptors mediate many important physiological functions, for example, in the urinary bladder. The corresponding gene is polymorphic, and the W64R (Trp64Arg) single nucleotide polymorphism has been associated with disease states such as obesity, type 2 diabetes and bladder dysfunction. While these clinical data suggest that the 64R variant is hypofunctional, previous in vitro...

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Identifiers

PMID: 19133996
DOI: 10.1111/j.1476-5381.2008.00014.x
PMCID: PMC2697764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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