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Article

Functional Characterization of the Obesity-Linked Variant of the β3-Adrenergic Receptor.

International journal of molecular sciences - 27 May 2021

Haji Esraa, Al Mahri Saeed, Aloraij Yumna, Malik Shuja Shafi, Mohammad Sameer

Abstract excerpt

Adrenergic receptor β3 (ADRβ3) is a member of the rhodopsin-like G protein-coupled receptor family. The binding of the ligand to ADRβ3 activates adenylate cyclase and increases cAMP in the cells. ADRβ3 is highly expressed in white and brown adipocytes and controls key regulatory pathways of lipid metabolism. Trp64Arg (W64R) polymorphism in the ADRβ3 is associated with the early development of type 2 diabetes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Adrenergic, beta-3

Source

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Identifiers

PMID: 34072007
DOI: 10.3390/ijms22115721
PMCID: PMC8199065

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