Polymorphism of the human beta3-adrenoceptor gene forms a well-conserved haplotype that is associated with moderate obesity and altered receptor function.

Abstract excerpt

k g / m 2 ) carried the 3 -Arg haplotype, compared with 11% of those who had a lower BMI (<31 kg/m 2 ), P = 0.02. Furthermore, BMI was ~2 kg/m 2 higher in Arg carriers compared with subjects who were Trp homozygous (P = 0.01) in the lower BMI group. No association of the 3 -Arg haplotype with metabolic parameters or blood pressure was found. F i n a l l y, the sensitivity for CGP12177 (a selective 3 - r e c e p t...

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