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Article

Internal ribosome entry segment-mediated initiation of c-Myc protein synthesis following genotoxic stress

1 Oct 2001

Abstract excerpt

Initiation of translation of the proto-oncogene c-myc can occur by either the cap-dependent scanning mechanism or by internal ribosome entry. The latter mechanism requires a complex RNA structural element that is located in the 5' untranslated region of c-myc, termed an internal ribosome entry segment (IRES). Recent work has shown that IRESs are used to maintain protein expression under conditions when...

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PMID: 11563982
DOI: 10.1042/0264-6021:3590183

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