Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effect of mutations on the p53 IRES RNA structure: implications for de-regulation of the synthesis of p53 isoforms.

RNA biology - 1 Jan 2000

Grover Richa, Sharathchandra Arandkar, Ponnuswamy Anand, Khan Debjit, Das Saumitra

Abstract excerpt

Earlier we have demonstrated the presence of internal ribosome entry site (IRES) within tumor suppressor p53 mRNA. Here we have mapped the putative secondary structure of p53- IRES RNA using information from chemical probing and nuclease mapping experiments. Additionally, the secondary structure of the IRES element of the wild-type RNA was compared with cancer-derived silent mutant p53 RNAs. These mutations might...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Doxorubicin
Share to Nucleic Acid Conformation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nucleotide Mapping

Share to Protein Isoforms

Share to RNA, Small Interfering

Share to Sequence Alignment

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 21317560
DOI: 10.4161/rna.8.1.14260

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 9 closest

Effect of mutations on the p53 IRES RNA structure: implications for de-regulation of the synthesis of p53 isoforms.PMID 21317560Read ↗

Effect of a natural mutation in the 5' untranslated region on the translational control of p53 mRNA.Semantic proximity Read ↗

Interaction of heterogeneous nuclear ribonucleoprotein C1/C2 with a novel cis-regulatory element within p53 mRNA as a response to cytostatic drug treatment.Semantic proximity Read ↗

Novel Dyskerin-Mediated Mechanism of p53 Inactivation through Defective mRNA TranslationSemantic proximity Read ↗

Internal ribosome entry segment-mediated initiation of c-Myc protein synthesis following genotoxic stressSemantic proximity Read ↗

Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner.Semantic proximity Read ↗

Probing the structure of the regulatory region of human transferrin receptor messenger RNA and its interaction with iron regulatory protein-1.Semantic proximity Read ↗

The importance of a single G in the hairpin loop of the iron responsive element (IRE) in ferritin mRNA for structure: an NMR spectroscopy study.Semantic proximity Read ↗

p53 directs conformational change and translation initiation blockade of human fibroblast growth factor 2 mRNA.Semantic proximity Read ↗

Secondary structure and the role in translation initiation of the 5'-terminal region of p53 mRNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.