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Article

Overexpression of c-Myc Alters G 1 /S Arrest following Ionizing Radiation

1 Mar 2002

Abstract excerpt

Study of the mechanism(s) of genomic instability induced by the c-myc proto-oncogene has the potential to shed new light on its well-known oncogenic activity. However, an underlying mechanism(s) for this phenotype is largely unknown. In the present study, we investigated the effects of c-Myc overexpression on the DNA damage-induced G(1)/S checkpoint, in order to obtain mechanistic insights into how deregulated...

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PMID: 11865060
DOI: 10.1128/mcb.22.6.1819-1833.2002

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