Article
Abolition of stress-induced protein synthesis sensitizes leukemia cells to anthracycline-induced death.
Blood - 1 Mar 2008
Gausdal Gro, Gjertsen Bjørn Tore, McCormack Emmet, Van Damme Petra, Hovland Randi, Krakstad Camilla, Bruserud Øystein, Gevaert Kris, Vandekerckhove Joël, Døskeland Stein Ove
Abstract excerpt
Anthracycline action has been thought to involve the neosynthesis of proapoptotic gene products and to therefore depend on protein synthesis for optimal effect. We found that inhibition of general, but not rapamycin-sensitive (cap-dependent), protein synthesis in the preapoptotic period enhanced anthracycline-induced acute myelogenous leukemia (AML) cell death, both in vitro and in several animal AML models....
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