Article
Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo.
Oncogene - 11 Sept 2003
Evans Joanne R, Mitchell Sally A, Spriggs Keith A, Ostrowski Jerzy, Bomsztyk Karol, Ostarek Dirk, Willis Anne E
Abstract excerpt
The 5' untranslated region of the proto-oncogene c-myc contains an internal ribosome entry segment and c-Myc translation can be initiated by cap-independent as well as cap-dependent mechanisms. In contrast to the process of cap-dependent initiation, the trans-acting factor requirements for cellular internal ribosome entry are poorly understood. Here, we show that members of the poly (rC) binding protein family,...
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