Article
Heterogeneous nuclear ribonucleoprotein C modulates translation of c-myc mRNA in a cell cycle phase-dependent manner.
Molecular and cellular biology - 1 Jan 2003
Kim Jong Heon, Paek Ki Young, Choi Kobong, Kim Tae-Don, Hahm Bumsuk, Kim Kyong-Tai, Jang Sung Key
Abstract excerpt
The c-myc proto-oncogene plays a key role in the proliferation, differentiation, apoptosis, and regulation of the cell cycle. Recently, it was demonstrated that the 5' nontranslated region (5' NTR) of human c-myc mRNA contains an internal ribosomal entry site (IRES). In this study, we investigated cellular proteins interacting with the IRES element of c-myc mRNA. Heterogeneous nuclear ribonucleoprotein C (hnRNP...
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