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Article

Alternative Translation of the Proto-oncogene c-mycby an Internal Ribosome Entry Site

1 Dec 1997

Abstract excerpt

The human proto-oncogene c-myc encodes two proteins, c-Myc1 and c-Myc2, from two initiation codons, CUG and AUG, respectively. It is also transcribed from four alternative promoters (P0, P1, P2, and P3), giving rise to different RNA 5'-leader sequences, the long sizes of which suggest that they must be inefficiently translated by the classical ribosome scanning mechanism. Here we have examined the influence of...

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PMID: 9405401
DOI: 10.1074/jbc.272.51.32061

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